Neutrophil Adhesion and Activation under Flow
نویسندگان
چکیده
منابع مشابه
Neutrophil adhesion and activation under flow.
Neutrophil recruitment into inflamed tissue in response to injury or infection is tightly regulated. Reduced neutrophil recruitment can result in a reduced ability to fight invading microorganisms. During inflammation, neutrophils roll along the endothelial wall of postcapillary venules and integrate inflammatory signals. Neutrophil activation by selectins and chemokines regulates integrin adhe...
متن کاملAdhesion of neutrophil leucocytes under conditions of flow.
By passing a suspension of polymorphonuclear leucocytes through a parallel-plate chamber their adhesiveness can be assessed by scoring the number of cells trapped on the lower plate, and the fluid shear stress can be defined for a given flow rate. Since the adhesiveness of the cell at the instant of collision must exceed the distractive shear if the cell is to stop, the kinetics of cell accumul...
متن کاملNeutrophil adhesion to fibrinogen and fibrin under flow conditions is diminished by activation and L-selectin shedding.
The adhesion of neutrophils (polymorphonuclear leukocytes [PMNs]) to immobilized fibrinogen/fibrin is mediated by beta2-integrins. However, the influence of physiologic flow conditions on neutrophil adhesion to these surfaces is poorly defined. In this report, the effect of flow and neutrophil activation on adhesion to immobilized fibrinogen and fibrin was examined. For the evaluation of (the d...
متن کاملMinimal platelet deposition and activation in models of injured vessel wall ensure optimal neutrophil adhesion under flow conditions.
Platelets at injured vessel wall form an adhesive surface for leukocyte adhesion. The precise relation between platelet adhesion and activation and leukocyte adhesion, however, is not known. We therefore used various models of injured vessel wall to form different patterns of platelet adhesion. The interaction of polymorphonuclear neutrophils (PMNs) was subsequently studied under flow condition...
متن کاملOptimal Neutrophil Adhesion Under Flow Conditions Minimal Platelet Deposition and Activation in Models of Injured Vessel Wall Ensure
Platelets at injured vessel wall form an adhesive surface for leukocyte adhesion. The precise relation between platelet adhesion and activation and leukocyte adhesion, however, is not known. We therefore used various models of injured vessel wall to form different patterns of platelet adhesion. The interaction of polymorphonuclear neutrophils (PMNs) was subsequently studied under flow condition...
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ژورنال
عنوان ژورنال: Microcirculation
سال: 2009
ISSN: 1073-9688,1549-8719
DOI: 10.1080/10739680802350104